简介:摘要目的探讨在无放疗条件下,采用腹壁下动脉插管化疗治疗中晚期宫颈癌的可行性。方法对丧失手术时机的晚期宫颈癌病人,采用F5输尿管导管经腹壁下动脉插管至腹主动脉下段,经插管推注5-Fu500mg/天,DDP20mg/天,每天一次,6—8天一疗程,每病人用药1—3疗程,疗程间隔3—4周,化疗结束后病灶明显缩小能手术者行手术治疗。结果共治疗63例宫颈癌病人,其中Ⅱb期23例,Ⅲ期38例,Ⅳ期2例。化疗结束后一周检查,17例完全缓解,27例部分缓解,有效率69.84%,17例病人化疗后行根治手术。结论腹壁下动脉插管化疗中晚期宫颈癌,疗效确切,简单经济,适于在无放疗条件的基层医院开展。
简介:ToleamwhetherHPV16E6/E7genescorrelatewithcervicalcarcinomaandprecancerouslesions.MethodsAmplificationandcloningofHPV16E6/E7geneswereperformedbyPCRandmolecularbiologicaltechniquesfortheirsequences.Cervicalcancer,CINⅡ-Ⅲandcervicitiswereconfirmedbypathologicdetections.ResultsDetectionratesofHPV16E6/E7inbiopsiesofcervicalcarcinoma,CINⅡ-Ⅲandcervicitiswereindividually70%,75%and65%.StatisticresultsshowthatthereisnodifferenceamongtheminHPV16E7detection.AlsotherisnodifferencebetweencervicalcancerandCINⅡ-ⅢinHPV16E6detection,however,bothwerehigherdetectionsthanincervicitisstatistically.ConclusionHPV16E6/E7genescorrelatewithcervicalcarcinomaandprecancerouslesions.E6genemightespeciallyfunctiononoccurrenceofcervicalcarcinomafromprecancerouslesions.