简介：Leptinistheproteinproductencodedbytheobese(ob)gene.Itisacirculatinghormoneproducedprimarilybytheadiposetissue.ob/obmicewithmutationsofthegeneencodingleptinbecomemorbidlyobese,infertile,hyperphagic,hypothermic,anddiabetic.Sincethecloningofleptinin1994,ourknowledgeinbodyweightregulationandtheroleplayedbyleptinhasincreasedsubstantially.Wenowknowthatleptinsignalsthroughitsreceptor,OB-R,whichisamemberofthecytokinereceptorsuperfamily.Leptinservesasanadipositysignaltoinformthebraintheadiposetissuemassinanegativefeedbackloopregulatingfoodintakeandenergyexpenditure.Leptinalsoplaysimportantrolesinangiogenesis,immunefunction,fertility,andboneformation.Humanswithmutationsinthegeneencodingleptinarealsomorbidlyobeseandrespondtoleptintreatment,demonstratingthatenhancingorinhibitingleptin'sactivitiesinvivomayhavepotentialtherapeuticbenefits.

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简介：多功能的organolithium开始者在环己烷溶剂被准备。这进程以在批把丁二烯的环己烷解决方案加到萘锂与重复单位的48丁二烯生产丁二烯oligomerdilithium开始了。在首先喂，环己烷和丁二烯环己烷答案的最小的集中装载的最大值必须在V环己烷1.33VTHF和40.6cN下面被控制。然后，SnCl4被增加，最后，包含Sn原子的多功能的organolithium开始者通过联合反应被综合。实验结果证明在批增加环己烷答案在克服一些困难是有效的，例如在环己烷的萘锂的不溶解性，在开始丁二烯的萘锂的低效率。在实践，苯能被环己烷完全代替，它不能仅仅从苯减少环境污染，而且克服在苯和环己烷之间的类似的沸腾的点引起的溶剂恢复的困难。与作为开始者，有更好的橡胶的硬化表演的塑造星的答案polymerized苯乙烯丁二烯橡胶(星S-SBR)，更低的滚动抵抗和更高的湿打滑包含Sn原子的多功能的organolithium准备了抵抗被获得。

简介：Inthispaper,itintroducedthemechanicalstructuredesignofthemultifunctionalwalkingrehabilitationrobot.WeusedtheSolidWorkstodesignandassembletherehabilitationrobot,andoptimizedtherehabilitationrobotbasedonergonomics.Theresultshowsthatthemultifunctionalwalkingrehabilitationrobothasthecharacteristicsofcompletefunctions,convenientoperation,compactstructureandsoon.Itcanmeettherequirementsofmedicalcareequipment,andeffectivelycompletethenursingworkofpatients.

简介：Currently,theagingofthepopulationhasbecometheworld’ssocialproblem.Withtheincreaseofagingpopulationandlotsofdisability,paralysismakesnursingcaremoredifficult.Becauseofmanyelderlycannotgettimelycare,thephenomenonthattheelderlyhavechronicdiseaseshasbecomemoreandmoreserious.Itisimportanttoresearchanddevelopanewproductwhichcanhelptheelderlyandthedisabledforimprovingthequalityoftheirlife.Thispapersuggestsanewtypeofmultifunctionalself-caringwheelchair-bed,whichiscombinedwithawheelchairandabed.Thebedcanrealizethefreeconversionamongusersitting,legliftingandlyingdown,andalsocanimplementthefunctionofturningonsides.Particularly,thewheelchaircanbeeasilyseparatedfromthebedandcombined,sothatpatientsandtheelderlycanmovefreelyusingit,andevenitcanbetransformedintoastandingtypetosatisfythepatient’sstandingdemand,andtoacertainextent,carryoutthepurposeofrehabilitation.

简介：BasedontheanalysisonexistingproblemsinChina'sforestryscience&technologysupportsystemandinviewoftherequirementsofmultifunctionalforestrydevelopmentforscience&technologysupport,thepaperconstructedascience&technologysupportframeworkformultifunctionalforestry,comprisingtechnologyinnovation,achievementstransfer,extensionandapplication,andpolicyguarantee.Majorcountermeasureswereproposedtoconsolidatethescience&technologysupporttomultifunctionalfores...

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简介：Opticalcamouflageisamagicalcapabilityofanimalsasfirstnoticedin1794byErasmusDarwininZoonomia,butcurrentbiomimeticcamouflagestrategiescannotbereadilyappliedincomplexenvironmentsinvolvingmultispectralandinparticularmulti-polarizationdetection.Herewedevelopaplasmonicapproachtowardbroadbandinfraredpolarimetriccrypsis,wherethepolarizedthermalemissionnearthepseudo-Brewsterangleisthemainsignalsourceandnoexistingpolarizingcamouflagetechniquehasbeendiscoveredinnature.Basedonall-metallicsubwavelengthstructures,anelectrodynamicresistance-reductionmechanismisproposedtoavoidthesignificantpolarization-dependentinfraredabsorption/radiation.Itisalsofoundthatthestructuredmetalsurfacepresentsgiantextrinsicanisotropyregardingthephaseshiftbetweenorthogonalpolarizationstates,whichhelpstorealizeultrahigh-efficiencyandtunablepolarizationconversioninanunprecedentedmanner.Finally,wenotethatthecatenaryopticaltheorymayprovideausefulmeanstoexplainandpredicttheseunusualperformances.

简介：TheE(envelope)proteinisthesmalleststructuralproteininallcoronavirusesandistheonlyviralstructuralproteininwhichnovariationhasbeendetected.WeconductedgenomesequencingandphylogeneticanalysesofSARS-CoV.Basedongenomesequencing,wepredictedtheEproteinisatransmembrane(TM)pro-teincharacterizedbyaTMregionwithstronghydrophobicityandα-helixcon-formation.Weidentifiedasegment(NH2-_L-Cys-A-Y-Cys-Cys-N_-COOH)inthecarboxyl-terminalregionoftheEproteinthatappearstoformthreedisulfidebondswithanothersegmentofcorrespondingcysteinesinthecarboxyl-terminusoftheS(spike)protein.ThesebondspointtoapossiblestructuralassociationbetweentheEandSproteins.OurphylogeneticanalysesoftheEproteinsequencesinallpub-lishedcoronavirusesplaceSARS-CoVinanindependentgroupinCoronaviridaeandsuggestanon-humananimalorigin.

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简介：DopedSrTiO3capacitor-varistormultifunctionalceramicswerefabricatedbyasinglesinteringprocess.ACcompleximpedanceanalysiswasperformedtoinvestigateelectricalfeaturesofgrainsandgrainboundariesforbothas-reducedceramicandreoxidizedceramics.Theresultsshowedthattheas-reducedceramicexhibitedinductiveresponseathighfrequenciesabove2MHz,whichisattributedtothecontributionofelectronbehaviorinsemiconductinggrains.Thehighfrequencyinductiveresponsedisappearedinimpedanceplotsofreoxidizedceramics.

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简介：Wearabledevicesthatmonitorthepersonalhealth,trackthehumanmotions,deliverdrugs,andgeneratemedicaltreatmentarehighlydemand-edinpersonalizedhealthcare.However,adesir-ablefeaturemissinginemergingwearabledevicesistheabilitytodeliveradvancedtherapyatthesame

简介：因为stabilizer是被看到的，新奇水溶性的做Mn的CdTe/ZnS核心壳量的合成点使用一个建议超声的助理方法和3-mercaptopropionic酸(MPA)。获得高光的紧张，包括pH价值，反应温度，倒流时间和空气，preparative以后处理被调查了。为做Mn的CdTe/ZnS的优秀荧光，最佳的条件是pH11，倒流温度100慣?慰慲敭整獲漠?敫潴??戠瑯?湩瘠捡潵愠摮愠畱潥獵猠汯瑵潩吗？

简介：这篇文章为综合盖住一个方法环境地友好的多功能的金属(钙，镁)有antioxidationproperty.These的油酸盐detergents多功能的金属(钙，镁)有antioxidation性质的油酸盐detergents用油可溶的液体抗氧化剂被综合(PPIBP，PPIBTSTBP，并且PPIBPDA)作为反应功能的materials.These，油可溶的液体抗氧化剂有潜力在综合为申请被用作功能的材料其它种s

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简介：Wepresentherethedevelopmentofcholesterol(Chol)-modifieddendrimersystemfortargetedchemotherapyoffolate(FA)receptor-expressingcancercells.Inourstudy,poly(amidoamine)(PAMAM)dendrimersofgeneration5(G5)werefunctionalizedstepby-stepwithChol,fluoresceinisothiocyanate(FI),andFAviaapoly(ethyleneglycol)(PEG)spacer(PEG-FA),andthenacetamidetoshieldtheirremainingsurfaceamines.ThesynthesizedG5.NHAc-Chol-FI-PEG-FA(forshort,G5-CFPF)dendrimerswereutilizedtoencapsulate10-hydroxycamptothecin(HCP),ahydrophobicanticancerdrug.WefindthateachG5-CFPFdendrimercanencapsulate13.8HCPmolecules.ThecomplexesshowaslowerreleaseprofilesofHCPinapH-dependentmannerthanthecontrolcomplexesformedusingthesamedendrimerswithoutCholunderthesameconditions.ThankstothetargetingroleplayedbyFA,thecomplexesdisplayaspecificinhibitionefficacytoFAreceptor-expressingcervicalcancercells.ThedesignedChol-modifieddendrimersmaybeadoptedasapromisingcarrierforapplicationintargetedcancertherapy.