简介：地震数据获得几何学设计的常规方法基于水平表面下的反射镜的假设，它经常不对复杂结构合适。我们从控制照明分析开始并且为面向目标的成像提出地震调查几何学设计的一个方法。方法需要初步的地震解释获得的一个速度模型。单程的Fourier有限差别的波浪增殖者被用来外推到表面的目标层上的飞机波浪来源。由分析波浪精力，在表面的分发从需要的目标层，射击或接收装置地点外推因为目标层成像能是坚定的。用SEG-EAGE盐模型的数字测试建议这个方法为为面向目标的成像证实特殊地震获得几何学布局是有用的。关键词地震获得几何学-控制照明-面向目标的成像第一作者刘守伟是Ph。D。在Tongji大学的学生。毕业并且在2002从石油的中国大学在应用地球物理收到了一个学士学位。从那时起，他在Tongji学习了大学主修稳固的地球物理。他兴趣包括地震照明，成像和移植速度分析。

简介：Weproposeasingle-stepimplementationofamuti-target-qubitcontrolledphasegatewithonecatstatequbit(cqubit)simultaneouslycontrollingn—1targetcqubits.Thetwologicstatesofac.qubitarerepresentedbytwoorthogonalcatstatesofasinglecavitymode.Inthisproposal,thegateisimplementedwithnmicrowavecavitiescoupledtoasuperconductingtransnionqutrit.Becausethequtritremainsinthegroundstateduringthegateoperation,decoherencecausedduetothequtrit5senergyrelaxationanddephasingisgreatlysuppressed.Thegateimplementationisquitesimplebecauseonlyasingle-stcpoperationisneededandneitherclassicalpulsenormeasurementisrequired.Numericalsimulationsdemonstratethathigh-fidelityrealizationofacontrolledphasegatewithonecqubitsimultaneouslycontrollingtwotargetcqubitsisfeasiblewithpresentcircuitQEDtechnology.Thisproposalcanbeextendedtoawiderangeofphysicalsystemstorealizetheproposedgate,suchasmultiplemicrowaveoropticalcavitiescoupledtoanaturalorartificialthree-levelatom.

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简介：Westudytarget-searchingprocessesonapercolation,onwhichahuntertracksatargetbysmellingodorsitemits.Theodorintensityissupposedtobeinverselyproportionaltothedistanceitpropagates.TheMonteCarlosimulationisperformedona2-dimensionalbond-percolationabovethethreshold.Havingnoideaofthelocationofthetarget,thehunterdeterminesitsmovesonlybyrandomattemptsineachdirection.Forlagerpercolationconnectivityp(＞～)0.90,itrevealsascalinglawforthesearchingtimeversusthedistancetothepositionofthetarget.Thescalingexponentisdependentonthesensitivityofthehunter.Forsmallerp,thescalinglawisbrokenandtheprobabilityoffindingoutthetargetsignificantlyreduces.Thehunterseemstrappedintheclusterofthepercolationandcanhardlyreachthegoal.

简介：ＡｉｒｂｏｒｎｅＴａｒｇｅｔＳｔａｔｅＥｓｔｉｍａｔｏｒ￥ＨａｏＪｉａｎｋａｎｇ；ＺｈａｎｇＭｉｎｇｌｉａｎ＆ＷｅｎＣｈｕａｎｙｕａｎ（Ｆａｃｕｌｔｙ３０５ｏｆＢｅｉｊｉｎｇＵｎｉｖｅｒｓｉｔｙｏｆＡｅｒｏｎａｕｔｉｃｓ＆ＡｓｔｒｏｎａｕｔｉｃｓＢｅ...

简介：瞄准：评估intra动脉的5氟尿嘧啶(5-FU)的时间依赖为先进肝细胞癌(aHCC)的治疗。方法：有aHCC和肝肝硬化的37个成年日本病人与联合intra动脉的5-FU，cisplatin(CDDP)，和甲酰四氢叶酸(LV)被对待。每个病人的日本综合阶段分数(JIS分数)是3或更多的。病人被划分成二个组，在组S的15个病人与6-h注入化疗在以后被对待(在12mg/h的LV，在10mg/h的CDDP，并且在250mg/m(2)的5-FU每4h)并且在组L的22个病人与24-h注入化疗(在12mg/h，在10mg/h的CDDP，和在每22h的250mg/m(2)的5-FU的LV)被对待。连续注入化疗经由合适的肝的动脉被执行为用一座植入的药水库的4wk的每5d。结果：有在化疗的4wk以后的部分回答的病人的百分比在组S是6.7%并且31.8%在组L。组L的幸存比组S的显著地好，与是的中部的生存时间在组L的496d和在组S的226d(P<0.05)。结论：连续24-hintra动脉的注入为aHCC是更有效的并且能显著地作为与6-h相比延长生存时间注入。

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简介：ＡＳＴＵＤＹＯＮＴＨＥＰＡＲＡＷＡＬＫＥＲＣＯＮＴＲＯＬＬＥＤＢＹＥＭＧＡＳＴＵＤＹＯＮＴＨＥＰＡＲＡＷＡＬＫＥＲＣＯＮＴＲＯＬＬＥＤＢＹＥＭＧＷａｎｇＲｅｎｃｈｅｎｇ；ＺｈａｎｇＰｅｉｙｕ；ＺｈａｎｇＪｉｃｈｕａｎ；ＪｉｎＤｅｗｅｎ（Ｄｅｐｔ．ｏｆ...

简介：Thepipelinesteelisusuallyproducedbyaddingniobiumandvanadiumalloyingelements.Thetitaniumalloyedpipelinesteelwasstudiedinthepapertoreducetheproductioncostandenhancethecompetitiveabilityofpipelinesteel.Thesteelcontaining0.070%Tiwasrefinedinthelaboratoryvacuumrefinefurnace.ThedynamicCCTcurveofdevelopedsteelwasconductedonGleeble-1500thermalsimulatorandmulti-passdeformationtestsofstudiedpipelinesteelwereperformedtosimulatetheCSPhot-rollingtechnology.Correspondingmicrostructureswereobservedandtheinfluencesofsuchtechnologyparametersasdeformationstrain,deformationtemperature,coolingrateandfinishingtemperatureetc.onmicrostructurewereanalyzed.ThedynamicCCTcurvewasobtained.ThetestresultsshowedthatthevolumefractionofacicularferriteinthemicrostructureofTi-microalloyedX70pipelinesteelincreasedobviouslywiththeincreaseofcoolingrateafterthermo-mechanicaldeformation.However,thevolumefractionofacicularferritevariesscarcelyafterthecoolingrateof20℃/s.InordertoobtainTi-microalloyedX70pipelinesteelwithexcellentcompoundmechanicalpropertieswhichhasacicularferriteasthemainidealmicrostructure,thecoolingrateshouldbecontrolledtobe20℃/sormore.Thehigherofthefinishingtemperature,themoreofthevolumeofacicularferriteandthelessofthevolumeofpolygonalferrite.Thequitefinemicrostructurecanbeobtainedbyloweringthefinish-coolingtemperature.TheresultshaveshownthatitispossibletoproducetheTi-additionX70pipelinesteelfromthepointofviewofmicrostructure.

简介：WepresentedasimpleroutetopreparenanoscaleCdTeurchinsinatri-n-octylphosphineoxide(TOPO)system.CdTeurchinsconsistedofacoreandseveralattachedarms.Thearmswereca.3nmwide,andtheirlengthscouldbecontrolledwiththereactiontime.TheauthorsinvestigatedtheopticalabsorptionandstructuralpropertiesofthepreparedCdTe.ThelengthsofthearmscouldbetunedintoCdTenanourchins,whichledtoachangeinthephotophysicalpropertiesofthenanoscaleCdTeurchins.Theresults,includingtransmissionelectronmicroscopy(TEM)andabsorptionspectra,indicatedthatmesoporoussilicaandaminopropyltriethoxysilane(APTES)contributedtotheformationofnanoscaleCdTeurchins.

简介：AbstractThe incidence and prevalence of asthma have increased remarkably in recent years. There are lots of factors contributing to the occurrence and development of asthma. With the improvement of sequencing technology, it has been found that the microbiome plays an important role in the formation of asthma in early life. The roles of the microbial environment and human microbiome in the occurrence and development of asthma have attracted more and more attention. The environmental microbiome influences the occurrence of asthma by shaping the human microbiome. The specific mechanism may be related to the immune regulation of Toll-like receptors and T cells (special Tregs). Intestinal microbiome is formed and changed by regulating diet and lifestyle in early life, which may affect the development and maturation of the pulmonary immune system through the intestinal-pulmonary axis. It is well-recognized that both environmental microbiomes and human microbiomes can influence the onset of asthma. This review aims to summarize the recent advances in the research of microbiome, its relationship with asthma, and the possible mechanism of the microbiome in the occurrence and development of asthma. The research of the microbial environment and human microbiome may provide a new target for the prevention of asthma in children who have high-risk factors to allergy. However, further study of "when and how" to regulate microbiome is still needed.

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简介：Parkinsonsdisease(PD)isacommon,progressiveneurodegenerativediseasecharacterisedbydegenerationofnigrostriataldopaminergicneurons,aggregationofα-synucleinandmotorsymptoms.Currentdopamine-replacementstrategiesprovidesymptomaticrelief,howevertheireffectivenesswearoffovertimeandtheirprolongeduseleadstodisablingside-effectsinPDpatients.ThereisthereforeacriticalneedtodevelopnewdrugsanddrugtargetstoprotectdopaminergicneuronsandtheiraxonsfromdegenerationinPD.Overrecentyears,therehasbeenrobustevidencegeneratedshowingthatepigeneticdysregulationoccursinPDpatients,andthatepigeneticmodulationisapromisingtherapeuticapproachforPD.Thisarticlefirstdiscussesthepresentevidenceimplicatingglobal,anddopaminergicneuron-specific,alterationsinthemethylomeinPD,andthetherapeuticpotentialofpharmacologicallytargetingthemethylome.Itthenfocusesonanothermechanismofepigeneticregulation,histoneacetylation,anddescribeshowthehistoneacetyltransferase(HAT)andhistonedeacetylase(HDAC)enzymesthatmediatethisprocessareattractivetherapeutictargetsforPD.Itdiscussestheuseofactivatorsand/orinhibitorsofHDACsandHATsinmodelsofPD,andhowtheseapproachesfortheselectivemodulationofhistoneacetylationelicitneuroprotectiveeffects.Finally,itoutlinesthepotentialofemployingsmallmoleculeepigeneticmodulatorsasneuroprotectivetherapiesforPD,andthefutureresearchthatwillberequiredtodetermineandrealisethistherapeuticpotential.

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简介：Itiswidelyacceptedthatthedesignofmorphologicalfilters,whichareoptimalinsomesense,isadifficulttask.Inthispaperanovelmethodforoptimallearningofmorphologicalfilteringparameters(Genetictrainingalgorithmformorphologicalfilters,GTAMF)ispresented.GTAMFadoptsnewcrossoverandmutationoperatorscalledthecurvedcylindercrossoverandmaster-slavemutationtoachieveoptimalfilteringparametersinaglobalsearching.Experimentalresultsshowthatthismethodispractical,easytoextend,andmarkedlyimprovestheperformancesofmorphologicalfilters.Theoperationofamorphologicalfiltercanbedividedintotwobasicproblemsincludingmorphologicaloperationandstructuringelement(SE)selection.Therulesformorphologicaloperationsarepredefinedsothatthefilter'spropertiesdependmerelyontheselectionofSE.Bymeansofadaptiveoptimizationtraining,structuringelementspossesstheshapeandstructuralcharacteristicsofimagetargets,andgivespecificinformationtoSE.Morphologicalfiltersformedinthiswaybecomecertainlyintelligentandcanprovidegoodfilteringresultsandrobustadaptabilitytoimagetargetswithclutterbackground.

简介：Neurodegenerationischaracterizedbytheprogressiveandpermanentlossofneurons.Degenerationtypicallyresultsinadebilitatinglossoffunctioninanotherwisehealthyperson.Neurodegenerativediseaseshaveenormousdirecthealthcarecosts,withsomeestimatesfordiseases,suchasAlzheimer’sdiseaseexceeding$36,000

简介：Theetiologyofneurodegenerativediseasesisdiverse,howevermostofthemsharecommoncharacteristics:accumulationofmisfoldedproteins,chronicandsustainedneuroinflammation,andthedysfunctionanddeathofcertainpopulationsofneurons.ThebrainofAlzheimer’sdisease(AD)patientspresents

简介：AnewmethodofunscentedextendedKalmanfilter(UEKF)fornonlinearsystemispresented.ThisnewmethodisacombinationoftheunscentedtransformationandtheextendedKalmanfilter(EKF).TheextendedKalmanfilterissimilartothatinaconventionalEKF.However,ineveryrunningstepoftheEKFtheunscentedtransformationisrunning,thedeterministicsampleiscaughtbyunscentedtransformation,thenposteriormeanofnonlinearityiscaughtbypropagating,buttheposteriorcovarianceofnonlinearityiscaughtbylinearizing.TheaccuracyofnewmethodisalittlebetterthanthatoftheunscentedKalmanfilter(UKF),however,thecomputationaltimeoftheUEKFismuchlessthanthatoftheUKF.