简介：AbstractPrecision medicine requires coordinated and integrated evidence-based combinatorial approaches so that diagnosis and treatment can be tailored to the individual patient. In this context, the treatment approach to mild obstructive sleep apnea (OSA) is fraught with substantial debate as to what is mild OSA, and as to what constitutes appropriate treatment. As such, it is necessary to first establish a proposed consensus of what criteria need to be employed to reach the diagnosis of mild OSA, and then examine the circumstances under which treatment is indicated, and if so, whether and when anti-inflammatory therapy (AIT), rapid maxillary expansion (RME), and/or myofunctional therapy (MFT) may be indicated.

简介：Facialspasmisclinicallyacommonlyen-counteredandobstinatedisease.Thisdiseasewastreatedbymildacupuncturewithasatisfac-torytherapeuticeffect,assummarizedinthefollowing.GENERALDATATherewere87casesintotalinthisseries,52males.and35females.Theoldestandtheyoungestpatientswere60and28yearsoldre-spectively.Thelongestandtheshortestcourses

简介：在这份报纸，我们建议函数的一个新类在Stepanov意义调用了加权的假S-asymptotically周期的函数并且包括作文定理在Banach空格探索它的性质。而且，存在，部分进化方程和nonautonomoussemilinear进化方程的加权的假S-asymptotically周期的温和答案的唯一被调查。一些有趣的例子被举说明主要调查结果。

简介：摘要BACKGROUNDCoronavirus disease 2019 (COVID-19) caused by a new Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a global pandemic. Gathered clinicopathological evidence in COVID-19 patients shows that alveoli injuries and interstitial changes are the major mechanisms of impaired O2/CO2 exchange. Few rehabilitation exercises concerning COVID-19 patients were reported. Here, we present a modified version of rehabilitation exercises based on the underlying mechanism of the disease to mild cases of COVID-19. These exercises aimed to improve the pulmonary function of patients and ease the expectoration process. Additionally, an essential branch of Traditional Chinese Medicine (TCM) named acupressure was integrated into the exercises to facilitate the recovery and maintenance of pulmonary function.METHODSFrom March 4, 2020 to May 5, 2020, a total of 60 COVID-19 patients who completed the full course of MRE were enrolled in this observational study. The diagnostic and classification criteria were based on the 7th edition of Diagnosis and Treatment Guideline of COVID-19 published by the National Health Commission of the People′s Republic of China. We prospectively gathered patients′ reported outcomes concerning respiration-related symptoms at four different time points, including: (I) at admission; (II) at the time of hospital discharge; (III) two weeks after discharge; (IV) four weeks after discharge. The reported respiratory symptoms included dry cough, productive cough, difficulty in expectoration, and dyspnea.RESULTSIn total, 60 confirmed mild COVID-19 cases were enrolled with a median age of 54 years old. The baseline prevalence for dry cough, productive cough, difficulty in expectoration, and dyspnea were 41.7%, 43.3%, 35.0%, and 50.0%, respectively. The pronounced decline in symptom prevalence was recorded over time. Interestingly, four weeks after discharge, we noticed a lower remission rate in productive cough and difficulty in expectoration.CONCLUSIONThe modified rehabilitation exercises were retrieved from the Eight-Section Brocade, and are specifically designed for rehabilitation of COVID-19 patients at home or health facilities. Based on current findings on pronouncedly improved remission rate in respiratory symptoms, we recommend the MRE as suitable rehabilitation exercise to smooth respiration and ease the expectoration process in mild COVID-19 cases.

简介：Longshorecurrentinstabilityisimportanttonearshorehydrodynamicandsedimenttransport.Thispaperinvestigatesthelongshorecurrentinstabilitygrowthmodelbasedexperimentaldatawithdifferentvelocityprofilesofslopes1:100and1:40byadoptingalinearshearinstabilitymodelwiththebottomfrictioneffects.Theresultsshowthat:(1)Onlybackshearmodeexistsintheinstabilityoflongshorecurrentforslope1:40andfrontshearandbackshearmodesmayexistslope1:100.(2)Thepeaksoflinearinstabilitygrowthmodeforslope1:100correspondtothreecases:thedominantpeakisformedbythejointactionofbothfrontshearandbackshear,orbybackshearalonewithouttheexistenceofthesmallerpeakorformedbyeitherthefrontshearorbackshear.(3)Bottomfrictioncandecreasethecorrespondingunstablegrowthratebutitcannotchangetheunstablefluctuationperiod.Theresultsoffluctuationperiod,wavelengthandspatialvariationobtainedbytheanalysisoflinearshearinstabilityareingoodagreementwithexperimentalresults.

简介：AbstractBackground:Keloids are benign fibrous growths that are caused by excessive tissue build-up. Severe keloids exert more significant effects on patients’ quality of life than do mild keloids. We aimed to identify factors associated with the progression from mild keloids to severe keloids, as distinct from those associated with the formation of keloids.Methods:In this retrospective case-control study, 251 patients diagnosed with keloids at West China Hospital between November 2018 and April 2021 were grouped according to the severity of lesions (mild [n = 162] or severe [n = 89]). We collected their basic characteristics, living habits, incomes, comorbidities, and keloid characteristics from Electronic Medical Records in the hospital and the patients’ interviews. Conditional multivariable regression was performed to identify the independent risk factors for the progression of keloids.Results:Eighty-nine patients (35.5%) were classified as having severe keloids. We found the distribution of severe keloids varied with sex, age, excessive scrubbing of keloids, family income, the comorbidity of rheumatism, disease duration, characteristics of the location, location in sites of high-stretch tension, the severity and frequency of pain, the severity of pruritus, and infection. Multivariable analysis revealed significant associations between severe keloids and infection (odds ratio [OR], 3.55; P = 0.005), excessive scrubbing of keloids (OR, 8.65; P = 0.001), low or middle family income (OR, 13.44; P = 0.021), comorbidity of rheumatism (OR, 18.97; P = 0.021), multiple keloids located at multiple sites (OR, 3.18; P = 0.033), and disease duration >15 years (OR, 2.98; P = 0.046).Conclusion:Doctors should implement more active and thorough measures to minimize the progression of mild keloids in patients who have any of the following risk factors: infection, excessive scrubbing of keloids, low or middle family income, comorbidity of rheumatism, multiple keloids located at multiple sites, and disease duration >15 years.

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简介：Themild-slopeequationisfamiliartocoastalengineersasitcaneffectivelydescribewavepropagationinnearshoreregions.However,itscomputationalmethodinCartesiancoordinatesoftenrendersthemodelinaccurateinareaswithirregularshorelines,suchasestuariesandharbors.Basedonthehyperbolicmild-slopeequationinCartesiancoordinates,thenumericalmodelinorthogonalcurvilinearcoordinatesisdeveloped.ThetransformedmodelisdiscretizedbythefinitedifferencemethodandsolvedbytheADImethodwithspace-staggeredgrids.Thenumericalpredictionsincurvilinearcoordinatesshowgoodagreementwiththedataobtainedinthreetypicalphysicalexperiments,whichdemonstratesthatthepresentmodelcanbeusedtosimulatewavepropagation,fornormalincidenceandobliqueincidence,indomainswithcomplicatedtopographyandboundaryconditions.

简介：这份报纸考虑在一个温和斜坡(1:40)上宣传的不规则的波浪的非线性的转变。不规则的波浪的二个盒子，机械地基于JONSWAP系列被产生，被用于这个目的。结果显示波浪高度服从瑞利分发在近海地点；在变浅的区域，然而，最大的波浪的高度被理论分布低估。在波浪地区，波浪高度能被合成Weibull分发接近。另外，在不规则的波浪以内联合的非线性的阶段被基于小浪的bicoherence调查。bicoherence系列思考参予联合的阶段的频率模式的数字与减少的水深度增加，，，这做阶段联合的度。在早期的碎以后，尽管阶段联合的度减少，很多更高的泛音波浪模式也涉及非线性的相互作用。而且，加的bicoherence显示与最强壮的本地非线性的相互作用有关的频率模式与减少的水深度变到更高的泛音。

简介：［1］Copeland,G.J.M.,1985.PracticalRadiationStressCalculationsConnectedwithEquationsofWavePropagation,CoastalEngineering,9,195～219.［2］DINGPingxing,KONGYazhenandSHIFengyan,1998.RadiationStressofWaterWavesandItsCalculation,JournalofEastChinaNormalUniversity,(1):82～87.(inChinese)［3］Kirby,J.T.andDalrymple,R.A.,1983.AParabolicEquationfortheCombinedRefraction-DiffractionofStokesWavesbyMildlyVaryingTopography,J.FluidMech.,136,453～466.［4］Kirby,J.T.,1986a.RationalApproximationsintheParabolicEquationMethodforWaterWaves,CoastalEngineering,10,355～378.［5］Kirby,J.T.,1986b.OpenLateralBoundaryConditionforApplicationintheParabolicEquationMethod,J.WaterwayPort.CoastalEng.,ASCE,112,460～465.［6］Longuet-Higgins,M.S.andStewart,R.W.,1960.ChangesintheFormofShortGravityWavesonLongWavesandTidalCurrents,J.FluidMech.,8,565～583.［7］Longuet-Higgins,M.S.andStewart,R.W.,1961.TheChangesinAmplitudeofShortGravityWavesonSteadyNon.uniformCurrents,J.FluidMech.,10,529～549.［8］Longuet-Higgins,M.S.andStewart,R.W.,1962.RadiationStressandMassTransportinGravityWaveswithApplicationtoSurfBeats,J.FluidMech.,13,481～504.［9］Longuet-Higgins,M.S.andStewart,R.W.,1964.RadiationStressinWaterWaves:aPhysicalDiscussionwithApplications,Deep-SeaRes.,11,529～562.［10］Longuet-Higgins,M.S.,1970.LongshoreCurrentsGeneratedbyObliquelyIncidentSeaWaves,J.Geophys,Res.,75,6778～6801.［11］Noda,E.K.,1974.Wave-InducedNearshoreCirculation,J.Geophys.Res.,79,4097～4106.

简介：Newhyperbolicmildslopeequationsforrandomwavesaredevelopedwiththeinclusionofamplitudedispersion.Thefrequencyperturbationaroundthepeakfrequencyofrandomwavesisadoptedtoextendtheequationsforregularwavestorandomwaves.Thenonlineareffectofamplitudedispersionisincorporatedapproximatelyintothemodelbyonlyconsideringthenonlineareffectonthecarrierwavesofrandomwaves,whichisdonebyintroducingarepresentativewaveamplitudeforthecarrierwaves.Thecomputationtimeisgreatlysavedbytheintroductionoftherepresentativewaveamplitude.Theextensionofthepresentmodeltobreakingwavesisalsoconsideredinordertoapplythenewequationstosurfzone.Themodelisvalidatedforrandomwavespropagateoverashoalandinsurfzoneagainstmeasurements.

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简介：Objective:　Toobservethechangesofevokedpotentialsafterseverebraininjuryandtheeffectofmildhypothermiaonacuteseverebraininjury.　　Methods:　Atotalof44patientswithsevereclosedheadinjury(GCS3-8,admittedwithin10hoursfrominjury)admittedfromMay1998toMarch1999wereselectedforthisstudy.Allpatientswereadmittedintotheintensivecareunitanddividedinto2groups,GroupA(GCS3-5)andGroupB(GCS6-8).Patientswerealsorandomlyassignedtoeithernormothermiaorhypothermiasubgroups.Patientsinthehypothermiagroupwerecooledto32-34℃.Mediannerveshort-latencysomatosensoryevokedpotentials(SLSEP)andbrainstemauditoryevokedpotentials(BAEP)wererecordedbeforecoolingand4,24,48,72,96and120hours,respectivelyaftercoolingandtemperatureresuming.SLSEPandBAEPweremeasuredatthesametimeinthenormothermiagroup(controlgroup).Thechangesofevokedpotentials(EP)wereanalyzedbystatisticalmethods.　　Results:　IntheGroupB,N20amplitudesinSLSEPandI/VamplitudesinBAEPaftermildhypothermiatreatmentinthehypothermiagroupdifferedsignificantlyfromthoseinthecontrolgroup(P<0.05).However,intheGroupA,nosignificantdifferenceinallparameterswasfound.　　Conclusions:　Theseresultsdemonstratethatmildhypothermiatreatment(32-34℃)intheGroupBhasasignificantneuroelectrophysiologicaleffectonseverebraininjury.Nevertheless,theeffectofmildhypothermiaintheGroupAisnotapparentandneedsfurtherstudying.

简介：Becauseofshoaling,refraction,friction,andothereffects,asurface-wavepropagatingonagentlyslopingbottomofslopewilleventuallybreak.Inthispaper,bynonlinearizingtheproblemandusingaperturbationmethod,ananalyticalsolutionforthevelocitypotentialisderivedtothesecondorderforthebottomslopeαandthewavesteepnessεinaEuleriansystem.Then,thewaveprofileandthebreakingwavecharacteristicsarefoundbytransformingtheflowfieldintoaLagrangiansystem.Byuseofthekinematicstabilityparameter(K.S.P.),newtheoreticalbreakercharacteristicsarederived.Thus,thelineartheoriesofotherscholarsareextendedtobreakingwaves.AComparisonofthepresentanalyticalsolutionwithexperimentalstudiesofotherscholarsshowsreasonableagreementexceptthatthebreakingdepthisunderestimated.

简介：Microtubes/rodsofthelayeredmetalhydroxidesaltcompoundCd2(OH)3(DS)·nH2O,whereDSstandsfordodecylsulfatesandwichedbetweentwoadjacentinorganicsheets,havebeensynthesizedforthefirsttimethroughamildhydrothermalreactionroute.Themicrotubes/rodshaveadiameterofabout1mandalengthrangingfromseveralmicronsto20m.Thegrowthprocessofmicrotubes/rodsundertheexperimentalconditionsemployedfollowsadissolution–recrystallizationroute.

简介：设Ｘ是Ｈｉｌｂｅｒｔ空间，ｅ~Ａｔ是Ｘ上的（１，Ａ）类半群．本文给出了用（λ－Ａ）~－１的性质来描述ｅ~Ａｔ谱的特征，同时也得到了Ｂａｎａｃｈ空间Ｘ中使（１，Ａ）类半群谱映射定理成立的一些充分条件．

简介：Traumaticbraininjury(TBI)isamajorpublichealthproblemthroughouttheworld.Morethan400000patientswithTBIintheUnitedStatesofAmericaandmorethanamillionpatientswithTBIinChinaareadmittedtohospitaleveryyear.HeadtraumaisalsoNo.1killerofyoungpeopleinthedevelopedcountriesaswellasinsomedevelopingcountries.Unfortunately,theoutcomeofpatientswithsevereTBIisstillpoorallovertheworld.ThemortalityofsevereTBIpatients(GCS3-8)inmajorityofhospitalsisover30%andverysevereTBIpatients(GCS3-5)isover80%withonly15%functionalrecovery.1,2However,recentadvanceincerebralprotectionbymild(35-33℃)tomoderatehypothermia(32-30℃)iscertainlyencouraging,whichbringsneurosurgeonsthehopetoimprovetheoutcomeofsevereheadinjuredpatients.

简介：Theactivitiesofgeomagneticstormsaregenerallycontrolledbysolaractivities.Thecurrentsolarcycle(SC)24isfoundtobemild;comparedtoSCs19–23,thestormoccurrenceandsizederivedbyaveragingtheoccurrencenumberandDstaroundthesolarmaximumarereducedbyabout50–82%and36–61%,respectively.Weestimateseparately,forSC19to24,therepeatintervalsbetweengeomagneticstormsofspecificDst,basedonfitsofpower-lawandlog-normaldistributionstothestormdataforeachSC.RepeatintervalsbetweensupergeomagneticstormswithDst≤–250nTarefoundtobe0.36–2.95year(s)forSCs19–23,butabout20yearsbasedonthedataforSC24.Wealsoestimatetherepeatintervalsbetweencoronalmassejections(CMEs)ofspecificspeed(VCME)sinceCMEsareknowntobethemaindriversofintensestormsandtherelatedstatisticsmayprovideinformationaboutthepotentialoccurrenceofsupergeomagneticstormsfromthelocationoftheSun.OuranalysisfindsthataCMEwithVCME≥1860km/smayoccuronceper3and5monthsinSC23and24,respectively.BasedonaVCME-Dstrelationship,suchafastCMEmaycauseastormwithDst=–250nTifarrivingattheEarth.BycomparingtheobservedgeomagneticstormstostormsexpectedtobecausedbyCMEs,wederivetheprobabilityofCMEcausedstorms,whichisdependentonVCME.ForaCMEfasterthan1860km/s,theprobabilityofaCMEcausedstormwithDst≤–250nTisabout1/5forSC23or1/25forSC24.AlloftheaboveresultssuggestthatthelikelihoodoftheoccurrenceofsupergeomagneticstormsissignificantlyreducedinamildSC.

简介：Amethodwasdevelopedtorealizequalityevaluationoneveryweld-spotinresistancespotweldingbasedoninformationprocessingofartificialintelligent.Firstly,thesignalsofweldingcurrentandweldingvoltage,asinformationsource,weresynchronouslycollected.Inputpoweranddynamicresistancewereselectedasmonitoringwaveforms.Eightcharacteristicparametersrelatingtoweldqualitywereextractedfromthemonitoringwaveforms.Secondly,tensile-shearstrengthofthespot-weldedjointwasemployedasevaluatingtargetofweldquality.Throughcorrelationanalysisbetweeneverytwoparametersofcharacteristicvector,fivecharacteristicparameterswerereasonablyselectedtofoundamappingmodelofweldqualityestimation.Atlast,themodelwasrealizedbymeansofthealgorithmsofRadialBasicFunctionneuralnetworkandsamplematrixes.Theresultsshowedvalidationsbyasatisfactioninevaluatingweldqualityofmildsteeljointon-lineinspotweldingprocess.

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