简介:BackgroundAnimalmodelsofhyperlipidemiawereestablishedbyfeedingrabbitswithhigh-cholesteroldiet,andthechangesinstructureandfunctionofcellmembraneinrabbitswerealsoreducedbyhyperlipidemia.Thus,thealternationsinerythrocytemembranelipidperoxidation(EMLP)andfluidityinrabbitsinducedbyhigh-cholesteroldietwereresearchedbyus.MethodsFourteenrabbitsweresubjectedtohigh-cholesteroldiet(cholesterol2g/d)andtheother14rabbitstocommondieteverydayforconsecutivetwomonths,plasmatotalcholesterol(TC),andbloodlipidsaswellasEMLPandfluidityweremeasuredbeforeandafterthefeeding.ResultsComparedwiththefeedingbefore,levelsofTCandlowdensitylipoproteincholesterol(LDL-C)weresignificantlyraised,thoseoferythrocytemembranelowdensitylipoproteincholesterol(MLDL-C),membraneconjugateddiene(MCD),erythrocytemalonaldehyde(RMDA)weresignificantlyincreased,whilethoseoferythrocytesuperoxidedismutase(R-SOD),membranefluidity(M-Flu)andmembranehighdensitylipoprotein-cholesterol(MHDL-C)weresignificantlydecreasedinexperimentalgroup,andtherewerenochangesincontrolgroup.ConclusionsHigh-cholesteroldietinduceslipidperoxidationandlowerfluidityoferythrocytemembrane.