简介：AIM:Toevaluatethecorrelationofshearwaveelastography(SWE)resultswithliverfibrosishistologyandquantitativefunctionreserve.METHODS:Weeklysubcutaneousinjectionof60%carbontetrachloride(1.5mL/kg)wasgivento12caninesfor24wktoinduceexperimentalliverfibrosis,witholiveoilgivento2controlcanines.At24wk,liverconditionwasevaluatedusingclinicalbiochemistryassays,SWEimaging,lidocainemetabolitemonoethylglycine-xylidide(MEGX)test,andhistologicfibrosisgrading.Clinicalbiochemistryassayswereperformedattheinstitutionalcentrallaboratoryforroutineliverfunctionevaluation.Liverstiffnesswasmeasuredintriplicatefromthreedifferentintercostalspacesandexpressedasmeanliverstiffnessmodulus(LSM).PlasmaconcentrationsoflidocaineanditsmetaboliteMEGXweredeterminedusinghigh-performanceliquidchromatographyrepeatedinduplicate.Liverbiopsysampleswerefixedin10%formaldehyde,andliverfibrosiswasgradedusingthemodifiedhistologicalactivityindexKnodellscore(F0-F4).Correlationsamonghistologicgrading,LSM,andMEGXmeasureswereanalyzedwiththePearsonlinearcorrelationcoefficient.RESULTS:At24wkliverfibrosishistologicgradingwasasfollows:F0,n=2(control);F1,n=0;F2,n=3;F3,n=7;andF4,n=2.SWELSMwaspositivelycorrelatedwithhistologicgrading(r=0.835,P<0.001).Specifically,theF4grouphadasignificantlyhigherelasticmodulusthantheF3,F2,andF0groups(P=0.002,P=0.003,andP=0.006,respectively),andtheF3groupalsohadasignificantlyhighermodulusthanthecontrolF0group(P=0.039).LSMwasnegativelyassociatedwithplasmaMEGXconcentrationsat30min(r=-0.642;P=0.013)and60min(r=-0.651;P=0.012),timeto?ofthemaximumconcentration(r=-0.538;P=0.047),andtheareaunderthecurve(r=-0.636;P=0.014).Multiplecomparisonsshowedidenticaldifferencesinthesethreemeasures:significantlylowerwithF4(P=0.037)andF3(P=0.032)ascomparedtoF0a

简介：Prostatic演算是普通的并且与前列腺的发炎被联系。最近，这发炎可以与前列腺carcinogenesis被联系，这被建议了。这研究的目的是在前列腺活体检视标本调查在prostatic演算和前列腺癌症(PCa)之间的关系。我们回顾地分析了经历了transrectalultrasonography(TRUS)和在2005年1月和2008年1月之间的前列腺活体检视的417个连续病人。基于活体检视调查结果，病人们被划分成良性的prostatic增生和PCa组。TRUS被用来检测prostatic演算并且测量前列腺体积。在PCa风险和年龄，浆液总数PSA层次，前列腺体积，和prostatic演算之间的关联被分析。耐心的年龄和PSA，以及在活体检视标本的prostatic演算的频率，在两个之间显著地不同这些组(P<0.05)。在PCa组，没有prostatic演算，格利森分数(GS)比在病人在有prostatic演算的病人是更高的(P=0.023)。用multivariate逻辑回归分析，我们发现了那耐心的年龄，浆液总数PSA和前列腺体积是为PCa的风险因素(P=0.001)，但是prostatic演算的存在没与PCa的增加的风险被联系(P=0.13)。在结论，尽管prostatic演算的存在没被显示是为PCa的一个风险因素，prostatic演算在有PCa的病人是更普通的并且在这些人之中与更高的GS被联系。

简介：

简介：无