简介：Thesolidaddofthefirstprotonatedzincoborophosphate,(H3O)Zn(H2O)2BP2O8·H2O(1),wassoventothermallysyn-thesizedbythereactionofZn(NO3)2·6H2OandH3BO3withH3PO4inamixedsolvent,andstructurallycharacterizedbysingle-ystalX-raydiffractionanalysis.ItcrystallizesinthehexagonalP6122,a=0.9604(4)nm,c=1.5297(6)nm,V=1.2218(8)nm^3,Dc=2.921g/cm^3,Z=6,F(000)=1080,μ=3.495mm^-1.Thestmchwefeaturesthatthetetrahedra-te-trahedrahdlcesinterconnectedbyoctahedraandstronghydro-gembondinteractionsformathree-dimensionalframework.Theprotonatedwatermoleculesarelocatedatuniquepositions.othercharacterizationsbyIRandthermalanalysisarealsode-scribed.
简介：研究了至今为止已发现的20个河外H2O超脉泽源的观测参数。多数河外H2O超脉泽源的光度在几十至几百个L⊙之内，但TXFS2226-184源的河外H2O超脉泽源光度达6100L⊙它属于射电星系类型，主要是由于其谱线轮廓较宽所造成的一种例外情况。所有20个河外H2O超脉泽源的系统速度约为几百到几千km·s^-1，16个河外H2O超脉泽源的峰值流量密度小于1Jy，但有4个河外H2O超脉泽源的峰值流量密度大于6Jy(6．2～16Jy)。通过对这些河外H2O超脉泽源的观测参数特征的分析和研究，得到这些观测参数之间的相关关系为：河外H2O超脉泽源的峰值流量密度的对数分别与系统速度的对数和距离的对数之间存在着反相关关系。而河外H2O超脉泽源的光度的对数与距离平方和峰值流量密度乘积的对数之间存在着正相关关系。
简介：AsimplespectrophotometricassayofH2O2andglucoseusingAgnanoparticleshasbeencarriedout.RelyingonthesynergisticeffectofH2O2reductionandultraviolet(UV)irradiation,Agnanoparticleswithenhancedabsorptionsignalsweresynthesized.H2O2servedasareducingagentintheAgnanoparticlesformationinwhichAg+wasreducedtoAg0byO2àgeneratedviathedecompositionofH2O2inalkalinemedia.Ontheotherhand,photoreductionofAg+toAg0underUVirradiationsalsocontributedtothenanoparticlesformation.ThesynthesizednanoparticleswerecharacterizedbyTEM,XPS,andXRD.TheproposedmethodcoulddetermineH2O2withconcentrationsrangingfrom5.010à7to6.010à5mol/L.Thedetectionlimitwasestimatedtobe2.010à7mol/L.SincetheconversionofglucosetogluconicacidcatalyzedbyglucoseoxidasewascompaniedwiththeformationofH2O2,thesensingprotocolhasbeensuccessfullyutilizedforthedeterminationofglucoseinhumanbloodsamples.Theresultswereingoodagreementwiththosedeterminedbyalocalhospital.Thiscolorimetricsensorthusholdsgreatpromisesinclinicalapplications.
简介：本文报道了Ｃ６Ｈ１２Ｏ６（ＮＨ４）２ＳＯ４Ｃ２Ｈ５ＯＨＨ２Ｏ（Ｃ２Ｈ５ＯＨ／Ｈ２Ｏ＝０．９０）体系在３５℃时体系溶解度和饱和溶液的折光指数，并绘出了体系相应的溶度图和饱和溶液的折光指数曲线图。结果表明：所研究的体系为四元体系Ｃ６Ｈ１２Ｏ６（ＮＨ４）２ＳＯ４Ｃ２Ｈ５ＯＨＨ２Ｏ中的一部分。当溶液中肌醇饱和时，溶度曲线落在约５０％的等醇水比面上。当（ＮＨ４）２ＳＯ４在溶液中达到饱和时，出现共饱点。其组成为（ＮＨ４）２ＳＯ４：２１０％，Ｃ６Ｈ１２Ｏ６：２．０８％，Ｃ２Ｈ５ＯＨ：４４７５％。同时出现分层，在富醇相随着乙醇浓度的增加，出现肌醇与硫酸铵共饱线。在富水相硫酸铵饱和溶度曲线落在约５％乙醇的等醇水比面上，折光指数曲线由三支组成，其中两条分别与Ｃ６Ｈ１２Ｏ６·Ｈ２Ｏ和（ＮＨ４）２ＳＯ４相对应，另外一条线与（ＮＨ４）２ＳＯ４和Ｃ６Ｈ１２Ｏ６·Ｈ２Ｏ的共饱线相对应
简介：AbstractObjective:The aim of this work was to explore the feasibility of in vivo and non-invasive monitoring of deuterium/hydrogen (2H/1H) exchange at the metabolic level upon exposure to heavy water (2H2O).Methods:The healthy female mice were randomly assigned to two groups after day 0 when both mice received standard drinking water. The treated mouse was fed with 2H2O (80%, v/v) and the control mouse fed with standard drinking water (H2O) over next 13 days. Real-time mass spectrometric analysis of volatile metabolism emitted through breathing and the skin was performed on days 1, 2, 3, 10, 12, and 13. Animal experiment was approved by the Laboratory Animal Ethics Committee of Jinan University (approval No. 20161117163322) on October 29, 2021.Results:We observed a replacement of 1H by 2H in 52 mass spectral features (60 2H/1H isotopologue pairs) for the mouse fed with 2H2O, but not for the control mouse. These included pyruvic acid and lactic acid, lysine and methyl-lysine as well as short-chain fatty acids comprising acetic acid, propionic acid, butyric acid and valeric acid.Conclusion:Secondary electrospray ionization-high resolution mass spectrometry allows monitoring in vivo2H-incorporation of metabolites in a non-invasive and real-time setup and opens new opportunities to use 2H tracing to extend current metabolic studies, especially those with a focus on anaerobic glycolysis, lysine methylation and gut microbiome via monitoring of short-chain fatty acids.
简介：对化合物[Na_2（H_2O）_（10）][Cu_4（H_2O）_（12）（H_2W_（12）O_（42））]·15H_2O（简称Na_2Cu_4W_（12））进行了体外抗肿瘤活性研究.应用四甲基偶氮唑盐（3-[4,5-dimethylthiazo-2-y]-2,5-diphenyltetrazoliumbromide,MTT）比色法分析Na_2Cu_4W_（12）对人肝癌细胞（HepG2）、人神经母细胞瘤细胞（SHY5Y）增殖抑制活性.采用光学显微镜观察肿瘤细胞的凋亡形态变化,用流式细胞术分析细胞周期和细胞凋亡,计算各期细胞比例及细胞凋亡率.结果表明,Na_2Cu_4W_（12）对HepG2和SHY5Y2种肿瘤细胞增殖半数抑制浓度IC_（50）值分别为5.3和10.2μmol·L~（-1）,且呈剂量依赖性.光学显微镜下处理组细胞出现皱缩、变圆、缩小等形态变化,不同浓度Na_2Cu_4W_（12）处理12h早期凋亡细胞所占的百分比显著增加且呈剂量依赖性.综上所述,Na_2Cu_4W_（12）能够抑制胞瘤细胞增殖,诱导细胞凋亡.
简介：Twooxo-vanadium(IV)complexes,[VO(C2O4)(2,2′-bipy)(H2O)]·C2H5OH(1)andVO(C2O4)(phen)(H2O)(2),where2,2′-bipy=2,2′-bipyridyl,phen=1,10-phenanthroline,weresynthesizedaspotentialfunctionalmodelsofvanadiumhaloperoxidases(VHPOs)inmixedsolventofethanolandwateratroomtemperature.Thecomplexeswerecharacterizedbyelementalanalysis,infrared(IR),UV-VisandX-raycrystallography.Structuralanalysesshowedthatvanadiumatomwascoordinatedbyaterminaloxygen,oneoxygenatomfromcoordinatedwater,twooxygenatomsfromthecarboxylategroupofoxalicacid,andtwonitrogenatoms(N1andN2)from2,2′-bipy/phen.Centralvanadiumatomsincomplexes1and2werebothinadistorted-octahedralenvironment,andsomeintermolecularhydrogenbondinglinkageswerealsoobservedineachcomplex.BrominationreactionactivityofthetwocomplexeswasevaluatedwithphenolredasorganicsubstrateinthepresenceofH2O2,Br-andphosphatebuffer,indicatingthattheycanbeconsideredasapotentialfunctionalmodelofVHPO.Inaddition,thermalanalysiswasalsoperformedanddiscussedindetail.
简介：无
简介：以FeSO4.7H2O,H3PO4,H2O2和NH3.H2O为原料合成纳米化的FePO4.1.5H2O,并将Li2CO3、FePO4.1.5H2O和葡萄糖混合球磨,在800℃下通过碳热还原合成LiFePO4/C。采用X射线衍射（XRD）、扫描电镜（SEM）、循环伏安（CV）和恒电流充放电测试研究了相同温度下,不同合成时间LiFePO4/C样品的结构、形貌及电化学性能。结果表明：在800℃12h下合成的样品具有最佳的电化学性能,在0.2C（1C=150mAh/g）倍率下放电,首次放电比容量为142.7mAh/g,经过20次充放电循环后容量基本保持不变。
简介：Thecopper(Ⅱ）complex[Cu3(nta)2(azpy)2(H2O2)]·6H2O(nta=nitrilotriacetate,azpy=4,4′-azobispyridine)hasbeensynthesizedandcharacterized.TheX-rayanalysisrevealsthattherearetwokindsofcopper(Ⅱ）coordinationenvironments.Cu(1)hasadistortedsquareplanesymmetryandCu(2)hasadistortedoctahedralsymmetry.Cu(1)islinkedtoCu(2)throughntaandboundtoCu(1C)byazpy,andCu(2)islinkedtoCu(2A)throughazpy,whichextendstotwo-dimensionalnetworkwithlargerhombus1.2nm×1.7nm.
简介：BackgroundTaxifolin(Tax)isanessentialnaturalantioxidant.MultiplestudieshaveshownthatTaxcanprotectcardiomyocytesfromischemia-reperfusioninjury.However,theunderlyingmechanismisstillunclear.MethodsH9C2cellswererandomlydividedintocontrol,H_2O_2group,Taxpretreatmentgroup(Tax+H_2O_2);Taxeffectgroup.CellactivitywasdetectedbyCCK-8andtheintracellularstructurewasobservedbytransmissionelectronmicroscopy.AutophagywasdeterminebyWesternblottinganalysisofBeclin-1,Bcl-2andPKC.ResultsTaxpretreatmentsignificantlyincreasedanti-apoptoticproteinBcl-2andautophagyproteinBeclin-1.ExpressionofPKCwasinhibitedbyTax.ConclusionsTaxpretreatmentcouldprotectH9C2cellsagainstH_2O_2-induceddamagethroughtheBcl-2andautophagypathways.
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![Crystal Structure and Bioactivity of Complex [Gd（C10<b style='color:red'>H</b>9N<b style='color:red'>2</b><b style='color:red'>O</b>4）（C10<b style='color:red'>H</b>8N<b style='color:red'>2</b><b style='color:red'>O</b>4）（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3]<b style='color:red'>2</b>·phen·4<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>](/image/thesis2 "Crystal Structure and Bioactivity of Complex [Gd（C10<b style='color:red'>H</b>9N<b style='color:red'>2</b><b style='color:red'>O</b>4）（C10<b style='color:red'>H</b>8N<b style='color:red'>2</b><b style='color:red'>O</b>4）（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3]<b style='color:red'>2</b>·phen·4<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>")
![Syntheses, Crystal Structures and Characterization of Two Zeotype Crystals of K4[Cr30（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） 3（OOCH） 6] <b style='color:red'>2</b>[ P<b style='color:red'>2</b>W18<b style='color:red'>O</b>62]· 9.5<b style='color:red'>H</b><b style='color:red'>2</b> <b style='color:red'>O</b> and K4[ Cr3<b style='color:red'>O</b>（ <b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3（ OOCH）6 ]<b style='color:red'>2</b>[ <b style='color:red'>H</b>3 P<b style='color:red'>2</b> W17Co（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） <b style='color:red'>O</b>61]· 20<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>](/image/thesis4 "Syntheses, Crystal Structures and Characterization of Two Zeotype Crystals of K4[Cr30（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） 3（OOCH） 6] <b style='color:red'>2</b>[ P<b style='color:red'>2</b>W18<b style='color:red'>O</b>62]· 9.5<b style='color:red'>H</b><b style='color:red'>2</b> <b style='color:red'>O</b> and K4[ Cr3<b style='color:red'>O</b>（ <b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）3（ OOCH）6 ]<b style='color:red'>2</b>[ <b style='color:red'>H</b>3 P<b style='color:red'>2</b> W17Co（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>） <b style='color:red'>O</b>61]· 20<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>")
![新型仲钨酸盐-B化合物[Na_<b style='color:red'>2</b>（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）_（10）][Cu_4（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）_（12）（<b style='color:red'>H</b>_<b style='color:red'>2</b>W_（12）<b style='color:red'>O</b>_（42））]·15<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>体外抗肿瘤活性研究](/image/thesis8 "新型仲钨酸盐-B化合物[Na_<b style='color:red'>2</b>（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）_（10）][Cu_4（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）_（12）（<b style='color:red'>H</b>_<b style='color:red'>2</b>W_（12）<b style='color:red'>O</b>_（42））]·15<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>体外抗肿瘤活性研究")
![Vanadium Haloperoxidases Model Compounds： Synthesis, Structural Characterization and Mimic Catalytic Bromination Activity of [VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（<b style='color:red'>2</b>,<b style='color:red'>2</b>′-bipy）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）]·C_<b style='color:red'>2</b><b style='color:red'>H</b>_5OH and VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（phen）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）](/image/thesis11 "Vanadium Haloperoxidases Model Compounds： Synthesis, Structural Characterization and Mimic Catalytic Bromination Activity of [VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（<b style='color:red'>2</b>,<b style='color:red'>2</b>′-bipy）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）]·C_<b style='color:red'>2</b><b style='color:red'>H</b>_5OH and VO（C_<b style='color:red'>2</b><b style='color:red'>O</b>_4）（phen）（<b style='color:red'>H</b>_<b style='color:red'>2</b><b style='color:red'>O</b>）")
![Synthesis,Structure and Characterization of Two—dimensional Network Copper Complex [Cu3（nta）<b style='color:red'>2</b>（azpy）<b style='color:red'>2</b>（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）<b style='color:red'>2</b>]·6<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>](/image/thesis16 "Synthesis,Structure and Characterization of Two—dimensional Network Copper Complex [Cu3（nta）<b style='color:red'>2</b>（azpy）<b style='color:red'>2</b>（<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>）<b style='color:red'>2</b>]·6<b style='color:red'>H</b><b style='color:red'>2</b><b style='color:red'>O</b>")
