简介:摘要目前“炎症,损伤”已成为冠心病研究领域的热点,白介素-8(IL-8)、白介素-1(IL-1)、肿瘤坏死因子α(TNF-α)是参与心肌梗死重要的炎症因子。IL-8、IL-1、TNF-α参与急性心梗的病生理过程是早期诊断心肌梗死及提示预后的参考指标之一,在心肌梗死极早期,尚不能做临床确诊时,病灶区附近便有IL-8、IL1、TNF-α的升高。因此早期发现并确定IL-8、IL-1、TNF-α来源的心肌区域对尽早诊断,及时处理有较大的价值。
简介:摘要目的检测非孕妇女、正常妊娠及子痫前期患者外周血中白介素-12(IL-12)和白介素-18(IL-18)水平,探讨Th1/Th2细胞因子在妊娠高血压疾病发病中的作用。方法孕20周后的子痫前期患者34例(轻度子痫前期15例,重度子痫前期19例),正常妊娠组32例,非妊娠对照组16例。取外周血进行流式细胞仪检测,选取CD28表达量最高者的淋巴细胞作为实验对象。采用ELISA法测定IL-12、IL-18,流式细胞仪测定Th1/Th2细胞比。结果正常妊娠组、非孕组及子痫前期组IL-12比较均存在显着性差异(P<0.001)。轻度子痫前期组、重度子痫前期组织与正常妊娠组IL-18比较均不存在显着性差异(P>0.05)。各组IL-18/IL-12浓度比比较正常妊娠组与子痫前期组比较存在显着性差异(P<0.0001)。IL-18/IL-12浓度比与Th1/Th2细胞比的相关性比较,呈明显负相关(P<0.01)。结论正常妊娠的IL-18/IL-12浓度比明显高于子痫前期,与Th1/Th2细胞比呈相反变化。
简介:Whyundertakeclinicaltrials?Beforeanewtreatmentcanbewidelyusedonpatients,itmustbeproventobesafeandeffective.Clinicaltrialsareumeansofconductingexperimentsonhumanstoyieldreliableresults.Forthisreason,theyareinthebestinterestsofpatients,clinicians,pharmaceuticalcompaniesandsocietyasawbele.
简介:摘要目的探讨白细胞介素-25和白细胞介素-7在荨麻疹患者中表达特点及临床意义。方法纳入我院2014年1月至2015年11月确诊为荨麻疹的患者100例,按照临床表现进行分期,急性期患者50例,慢性期患者50例,同时纳入我院体检科检查的健康志愿者作为对照组,收集患受试者的血清,采用酶联免疫法检测患受试者血清白细胞介素-25和白细胞介素-7的表达水平,对患者及受试者血清白细胞介素-25和白细胞介素-7进行比较及相关性分析。结果荨麻疹的急性期患者白细胞介素-7、白细胞介素-25表达水平高于对照组及慢性期患者,差异比较具有统计学意义(P<0.05),白细胞介素-7与白细胞介素-25的表达水平之间具有相关性(P<0.05)。结论荨麻疹患者白细胞介素-7、白细胞介素-25水平表达增高,且急性期表达水平要高于慢性期,提示两者参与了荨麻疹急性发作的病理过程,与疾病的严重程度具有一定的相关性。
简介:Mostcytotoxicchemotherapydrugsexerttheireffectbyinhibitingoneormoreoftheprocessesinvolvedincelldivision.Itappearsthatthefateofcellsdamagedbychemotherapyistodieprimarilybyinductionofapoptosis(prograrmnedcelldeath).Chemotherapyisgenerallyusedtotreatcanceratanadvancedorearlystage.
简介:AbstractAntiphospholipid syndrome (APS) is a thromboinflammatory disease with a variety of clinical phenotypes. Primary thrombosis prophylaxis should take an individualized risk stratification approach. Moderate-intensity vitamin K antagonist such as warfarin remains the primary strategy for secondary thrombosis prophylaxis among APS patients, especially for patients with predominantly venous disease. For now, direct oral anti-coagulants should be avoided in most APS patients, especially those with history of arterial manifestations. Obstetric APS management should be tailored based on an individual patient’s antiphospholipid antibody profile, and obstetric and thrombotic history. Pharmacological agents beyond anticoagulants may be considered for the management of microthrombotic and nonthrombotic manifestations of APS, although more data are needed. A relatively recent discovery in the area of APS pathogenesis is the implication of neutrophil extracellular traps in thrombin generation and initiation of inflammatory cascades. APS is a complex thromboinflammatory disease with a broad clinical spectrum. Personalized therapy according to an individual’s unique thrombosis and obstetric risk should be advocated.
简介:PurposeToconfirmtheeffectsofacupuncture,andChinesemedicinesincontrollingthewithdrawalsymptomsfromtheopium-likedrugs.Method96heroin-dependentsubjectsweredividedintofourgroups,whichweretreatedrespectivelybywesternmedicine(Agroup),acupuncture(Bgroup),Chineseherbs(Cgroup),andacupuncture&Chineseherbs(Dgroup).Before,duringandaftertreatment,theconcentrationofserumtestosteroneandprolactin,andimmunefunctions(serumCD3+、CD4+、CD8+andCD4+/CD8+)weretested.ResultsAftertreatment,theconcentrationofserumtestosteroneinAandBgroupwerehigherthanbeforeandduringtreatment,andinCandDgroup,duringtreatmentwerehigher.Inthefourgroups,theconcentrationofserumprolactinbeforetreatmentwasthehighest.ThelevelsofCD3+、CD4+、CD8+andCD4+/CD8+werelowestbeforetreatmentandhighestaftertreatment.ConclusionAcupunctureandChinesemedicineseffectiveinrelievingspasmandpaincancontroltheopium-likedrugwithdrawalsymptomstodifferentdegrees,especiallyacupuncture.However,acupuncturecannoteasethewithdrawalsymptomscompletely.AcupuncturedoesnotstrikinglycooperatewiththeChinesemedicineseffectiveinrelievingspasmandpain(includingM-receptorantagonists).Indetoxification,theJiajipointsaretheprimaryonesandsymptom-basedpointsthesecondaryones.
简介:<正>Maintainingleannessandaphysicallyactivelifestyleduringadulthoodreducessystemicinflammation,anunderlyingfactorinmultiplechronicdiseases.Theanti-inflammatoryinfluenceofnear-dailyphysicalactivityinloweringC-reactiveprotein,totalbloodleukocytes,interleukin-6,andotherinflammatorycytokinesmayplayakeyroleinloweringriskofcardiovasculardisease,certaintypesofcancer,type2diabetes,sarcopenia,anddementia.Moderateexercisetrainingcausesfavorableperturbationsinimmunityandareductioninincidenceofupperrespiratorytractinfection(URTI).Duringeachboutofmoderateexercise,anenhancedrecirculationofimmunoglobulins,neutrophils,andnaturalkillercellsoccursthatpersistsforupto3-hpost-exercise.Thisexercise-inducedsurgeinimmunecellsfromtheinnateimmunesystemistransientbutimprovesoverallsurveillanceagainstpathogens.Asmoderateexercisecontinuesonanear-dailybasisfor12—15weeks,thenumberofsymptomsdayswithURTIisdecreased25%—50%comparedtorandomizedsedentarycontrols.EpidemiologicandanimalstudiessupportthisinverserelationshipbetweenURTIriskandincreasedphysicalactivity.
简介:血液透析(HD)通过血液、透析膜、透析液间相互反应可激活外周单个核细胞并影响到机体细胞因子产生,而细胞因子白细胞介素-1β(IL-1β)、白细胞介素(IL-6)为炎性介质,在致热原反应中起一定作用,同时已知IL-6、肿瘤坏死因子-α(TNF-α)是导致肾小球基质增生、系膜细胞增殖、肾小球硬化及病变进展、肾功能恶化重要因素之一.此项研究采用酶免疫吸附(ELISA)双夹心抗体法测定30例健康对照组,30例慢性肾功能不全(CRF)未血液透析及60例CRF血液透析患者透析前后白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平.并检测HD患者第一次血液透析时,单次透析前后上述指标改变,以探讨CRF患者细胞免疫功能的改变及透析对其影响.