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简介：Artesunaeisaderivativeofqinghaosu,withasesquiterpenestructure.Thespecificactionandtheclinicalusesofartesunateareonthepreliminarystage,ontheonehand,artesunatehasspecificactionofbothantiinflammationandantivirus,andalsohasprotectiveeffectonthepulmonaryalveolarmacrophages,whuichmaybeadvantageoustothetreatmentoftheairwaynon-specificinflammationofasthma,.Ontheotherhand,qinghaousuhastheactivitiestorelaxvascularsmoothmuscleandtocausehypotension.Theexpectorantaction,theantitussiveactionandtheantuiasthmaticactionofqinghaosuwerepreported.Artesunatemayalsohaveantiasthmaticactivity,becausetheantimalarialpotencyofartesunateisstrongerthanthatofqinghaosu,andArtesunatecanblockCa^2+influxbyinhibitingcalcium-dependentchloridecurrent.Themainaimsofthispaperaretoinvestigatethesite,themode,andthemechanismofartesunateactiononisolatedtrachealsmoothmusclefromtheguinea-pig.

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简介：ＥｆｅｃｔｓｏｆＡｒｔｅｓｕｎａｔｅｏｎＴｒａｃｈｅａｌＳｍｏｏｔｈＭｕｓｃｌｅｆｒｏｍｔｈｅＧｕｉｎｅａｐｉｇＰｏｓｔｇｒａｄｕａｔｅ∶ＭａｏＳｈｅｎｇＹａｎｇＳｕｐｅｒｖｉｓｏｒ∶ＡｓｏｃｉａｔｅＰｒｏｆ．ＪｉａｎＣｈｕＸｉａｏＤｅｐａ...

简介：ObjectiveToinvestigatethealterationsofL-typecalciumcurrent(IcaL)inabdominalaorticligation-inducedhypertrophiedratheartsandtheeffectoflosartanonthesealterations.METHODSCardiachypertrophywasinducedbyabdominalaorticligationinrats.TorecordIcaL,whole-cellpatch-clamptechniquewasused.RESULTSMembranecapacitancewaslargerinhypertrophiedcells(148±29pF)thaninsham-operatedcells(102±14pF,P<0.01)andlosartan-treatedcells(118±27,P<0.01).ThemaximalpeakIcaLWasincreasedfrom-835±124pAinsham-operatedcellsto-1404+_417pAinhypertrophiedcells(P<0.01),thecorrespondingIcaLdensitywasincreasedfrom-7.5±1.8pA.pF^1to-10.5±2.2pA.pF^1(P<0.01),whiletheywerereducedto-956-2:170pF(P<0.01)and-8.2±1.6pA.pF^1(P<0.05)respectivelyinlosartan-treatedcells.Themembranepotentialofhalfmaximalactivationofthehypertrophiedcells(-20.6±1.0mV)shiftedtomorenegativepotentialsthansham-operatedcells(-15.6±1.6mV,P<0.01)andlorsartan-treatedcells(-17.4±1.0mV,P<0.01).Theslopeoftheactivationcurveofhypertrophiedcells(5.7±0.4)wasdecreasedslightlythansham-operatedcells(6.4±0.5,P<0.05).Themembranepotentialofhalfmaximalinactivationofhypertrophiedcells(-27.6±1.9mV)shiftedtomorepositivepotentialsthansham-operatedcells(-31.4±2.2mV,P<0.05).Theslopeofinactivationcurveswerenotdifferentinthethreegroups.

简介：Podophyllotoxone,4β-hydroxy-2,3-en-apopicropodophyllin,and4-deoxy-4β-azado-2,3-en-apo-picropodophyUincaneasilytransformto4-hydroxy-dehydropicropodophyUin,dehydroanhydropicropodophllyinand4-amino-dehydropicropodophyllinrespectivelyindifferentconditions.Thesepropertiesremind.ustobecarefulinhandlingrelatedcompoundsinsimilarconditions.

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简介：AIM:ToexaminetheprotectiveeffectsofGinkgobilobaextract(GbE)onthelearningandmemoryintheAlzheimerdisease(AD)modelinducedbyaluminumsaltinrats,andtoexaminethepotentialmechanisms.METHODS.TheADmodelofratswasinducedbyadministrationanddrinkingofaluminumchloridesolution.Theabilitiesofspatialleafingand

简介：研究地西泮、苯巴比妥、普萘洛尔和西咪替丁对地西泮氧化代谢的影响及其药酶蛋白的初步分析，应用ＨＰＬＣ，ＳＤＳ聚丙烯酰胺凝胶电泳和薄层扫描测定地西泮及其代谢物，并对大鼠肝微粒体和酶蛋白进行分离和含量测定。结果表明地西泮、普萘洛尔和西咪替丁使肝微粒体中Ｐ４５０含量明显降低。地西泮和普萘洛尔明显抑制地西泮Ｃ３羟化活性，大剂量普萘洛尔尚能抑制地西泮Ｎ脱甲基。苯巴比妥明显诱导Ｐ４５０生成，增强地西泮Ｎ脱甲基和Ｃ３羟化酶活性及分子量为５１，０００和５９，０００的电泳蛋白带，而地西泮、普萘洛尔则呈抑制作用。并发现，地西泮Ｎ脱甲基酶活性和分子量为５９，０００蛋白含量呈线性相关（Ｐ＜０．０５），而Ｃ３羟化酶活性则与５１，０００蛋白含量呈线性相关（Ｐ＜０．０１）。因此地西泮Ｃ３羟化代谢可能与５１，０００的Ｐ４５０酶蛋白有关，而Ｎ脱甲基代谢则可能与５９，０００的Ｐ４５０酶蛋白有关。

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简介：ObjectiveToinvestigatetheeffectsofselectivenitricoxidesynthase(NOS)inhibitorsondentategyrusneurogenesisafterdiffusebraininjury(DBI)intheadultratbrain.MethodsAdultmaleSDratsweresubjectedtodiffusebraininjury(DBI)model.Byusingsystemicbromodeoxyuridine(BrdU)tolabeldividingcells,wecomparedtheproliferationrateof

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简介：AIM:ToexploretheeffectsofCompoundYi-Zhi(YZC)onlearningandmemorycapacityandfreeradicalmetabolisminD-galactoseinducedmicedementiamodel.METHODS:ThemicedementiamodelwasinducedbyadailyD-galactose0.15g/kgscfor45daysandafter5days'D-galactoseinjection,themiceweretreatedwiththreedosesofYZC

简介：AIMToinvestigatetheeffectsofCapsuleYi-Zhi(CYZ)onlearningandmemorydisorderandbeta-amyloidproteininducedneurotoxieityinrats.MethodsVariousdosesofCYZwereadministeredtoSprague-Dawley(SD)ratsfor8days,twiceaday.Thenscopolaminehydrobromide(Sco)intraperitonealinjectionwasperformedoneachratandthe

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简介：AIMProstaglandinA1(PGA1)isacyclopentenoneprostaglandin.Recently,wereportedthatPGA1caninhibitexcitotoxin-inducedapoptosisofstriatalneuronsinvivoandrotenone-inducedapoptosisofculturedSH-SY5Ycells,suggestingthatPGA1mayhaveneuroprotectiveefficacy,possiblymediatedbyinhibitionofNF-kBactivation.ThepresentstudyevaluatedtheneuroprotectivepotentialofPGA1anditseffectonIKK/I(B/NF-kB/c-mycsignalingpathwayinratmodelsofpermanentfocalcerebralischemia.METHODSPermanentmiddlecerebralarteryocclusion(pMCAO)modelwasconstructedbyintraluminalsuturecannulationthroughtheinternalcarotidarteryinWistarrats.