简介：Anovelseriesofpyrido[1,2-e]purin-4(3H)-onederivativescontainingpolarsubstituentson5'-positionweredesignedandpreparedaspotentialPDE5inhibitors.Thispaperreportsthesyntheticroutes,1H-NMRdata,andthePDE5inhibitoryactivitiesofthetargetcompounds.Thepolarpiperazinylgroupcontained(on5'-position)compound,3B2,showedthehighestactivityamongthetestedderivativesbutlesspotencythansildenafil1.
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![Design and Synthesis of Pyrido[1,2-<b style='color:red'>e</b>]purin-4（3H）-one Derivatives as Potential PDE 5 Inhibitors](/image/thesis0 "Design and Synthesis of Pyrido[1,2-<b style='color:red'>e</b>]purin-4（3H）-one Derivatives as Potential PDE 5 Inhibitors")