摘要
Theexpressedproteinswereextractedfromhumanbenignprostatichyperplastictissuesobtainedwithtransurethralresectionoftheprostatebeforeandaftertheirirradiationwithradioactivenuclide.Theproteinswereseparatedbytwo-dimensionalgelelectrophoresisandanalyzedbymassspectrometry.Fourproteinsweredifferentiallyexpressedandwereidentifiedwithadatabasesearch.ThreewereassociatedwiththeregulationofcellmotionandonewaslactatedehydrogenaseB,whichplaysanimportantroleintheprocessofcellenergymetabolismandcellstatechangesintissue.Thecomparativeproteomicanalysisindicatesthatafterirradiationwithradioactivenuclide,changesoccurinhumanbenignprostatichyperplasticcells,andassociatedproteinsareexpressed.Analysisoftheseproteinsshouldhelptoidentifythemechanisminvolvedwhenhumanprostatichyperplasiaistreatedbyirradiationwithradioactivenuclide.
出版日期
2010年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)