摘要
Proteomicsisthestudyofproteinsandtheirinteractionsinacell.WiththecompletionoftheHumanGenomeProject,theemphasisisshiftingtotheproteincomplimentofthehumanorganism.Becauseproteomereflectsmoreaccuratelyonthedynamicstateofacell,tissue,ororganism,muchisexpectedfromproteomicstoyieldbetterdiseasemarkersfordiagnosisandtherapymonitoring.Theadventofproteomicstechnologiesforglobaldetectionandquantitationofproteinscreatesnewopportunitiesandchallengesforthoseseekingtogaingreaterunderstandingofdiseases.High-throughputproteomicstechnologiescombiningwithadvancedbioinformaticsareextensivelyusedtoidentifymolecularsignaturesofdiseasesbasedonproteinpathwaysandsignalingcascades.Massspectrometryplaysavitalroleinproteomicsandhasbecomeanindispensabletoolformolecularandcellularbiology.Whilethepotentialisgreat,manychallengesandissuesremaintobesolved,suchasmininglowabundantproteinsandintegrationofproteomicswithgenomicsandmetabolomicsdata.Nevertheless,proteomicsisthefoundationforconstructingandextractingusefulknowledgetobiomedicalresearch.Inthisreview,asnapshotofcontemporaryissuesinproteomicstechnologiesisdiscussed.
出版日期
2007年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
