Variation and evolution of NP genes of human avian H5N1 virus strains-中国期刊网

摘要 InordertorevealvariationandrevolutionofNPgenesofhumanavianH_5N_1influenzavirusstrains,theNPgeneofahumanavianH_5N_1influenzavirusstraininGuangdongwassequencedandtheglobalNPgenesofstrainswereretrieved.ThesequenceswereanalyzedbyDNAStar5.0,andtheevolu-tionaryspeedwasstudiedwithreferencetotheepidemiologicaldata.ItwasfoundthatNPgenesof45strainsduring1997-2006werehomologicallyclassifiedintothreegroups:strainsin1997-1998,strainsin2004-2005andstrainsfrom2003to2006.Therewere35substitutionsinNPsinallstrainsaccountingforaratioof7.03%(35/498).Anadditionalglycoproteindomain(NGT_(430-432))wasfoundinNPgenesinthestrainsof2003-2006,themutationofN_(370)SinGD-01-06resultedinoccurrenceofonemoreglyco-proteindomain(NES_(368-370)).Inthesynonymousvariation,K_svaluesinNPwere2.03×10~(-5)-2.55×10~(-5)Nt/dandK_avaluesinNPwere1.58×10(-6)-3.10×10~(-6)Nt/d.Theredidn′texistobviouslyselectivepres-sure.Anadditionalglycoproteindomainineverystrainof2003-2006andonemoreinstrainGD-01-06mightchangetheantigenicityofhumanavianH_6N_1influenzavirus.ThevariationonhumanavianH_5N_1influenzastrainsoccurredfrequentlyinthenaturalworld,whichwouldresultinhighprobabilityofhu-man-humantransmissionalongwiththenaturalevolutionofthevirus.

1Venkata R.S.K. Duvvuri;Bhargavi Duvvuri;Wilfred R. Cuff;Gillian E. Wu;Jianhong Wu. Role of Positive Selection Pressure on the Evolution of H5N1 Hemagglutinin.分子生物学,2009-01.
2Yang Lei,Zhao Xiang,Li Xiyan,Bo Hong,Li Duo,Liu Jia,Wang Dayan. Case report for human infection with a highly pathogenic avian influenza A(H5N6) virus in Beijing, China 2019.医药卫生,2020-08.
3Jingxin Li,Li Zhang,Linlin Bao,Yuxiao Wang,Lin Qiu,Jialei Hu,Rong Tang,Huiyan Yu,Jun Shan,Yan Li,Chuan Qin,Fengcai Zhu. A broadly neutralizing human monoclonal antibody against the hemagglutinin of avian influenza virus H7N9.医药卫生,2022-12.
4. 人类和H5N1的认识过程.公共卫生与预防医学,2004-03.
5Gabriele Neuman;Hualan Chen;George F Gao;Yuelong Shu;Yoshihiro Kawaoka. H5N1 influenza viruses： outbreaks and biological properties.细胞生物学,2010-01.
6Zhiping Sun,Yun Qian,Norio Ogata,Xia Cai,Wendong Han,Youhua Xie,Hirofumi Morino,Koushirou Sogawa,Takashi Shibata,Di Qu. Effect of chlorine dioxide on avian influenza A (H7N9) virus.医药卫生,2022-12.
7Yanlai Lu Zhen Li Chi Ma Hao Wang, Jing Zheng Lianxian Cui Wei He. The interaction of influenza H5N1 viral hemagglutinin with sialic acid receptors leads to the activation of human γδT cells.免疫学,2013-06.
8王雨;刘笑芬. 禽流感A（H5N1）和A（H7N9）的最新报道.治疗学,2017-04.
9. 中国香港科学家研究H5N1致命之谜.畜牧兽医,2005-12.
10Mohd Danishuddin Asad U. Khan. Phylogenetic Analysis of the Neuraminidase Gene Reveals that the H5N1 Strains Prevalent in Chickens During 2006 Bird Flu Outbreaks in Two Regions of Maharashtra, India Are Genetically Different.分子生物学,2009-01.

Variation and evolution of NP genes of human avian H5N1 virus strains

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Variation and evolution of NP genes of human avian H5N1 virus strains

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