摘要
Amyotrophiclateralsclerosis(ALS)isafatalprogressivedisordercharacterizedbytheselectivedegenerationofmotorneurons(MN).TheimpactofperipheralimmunestatusondiseaseprogressionandMNsurvivalisbecomingincreasinglyrecognizedintheALSresearchfield.Inthisreview,webrieflydiscussfindingsfrommousemodelsofperipheralnerveinjuryandimmunodeficiencytounderstandhowtheimmunesystemregulatesMNsurvival.Weextendtheseobservationstosimilarstudiesinthewidelyusedsuperoxidedismutase1(SOD1)mousemodelofALS.Last,wepresentfuturehypothesestoidentifypotentialcausativefactorsthatleadtoimmunedysregulationinALS.Thelessonsfromprecedingworkinthisareaoffernewexcitingdirectionstobridgethegapinourcurrentunderstandingofimmune-mediatedneuroprotectioninALS.
出版日期
2017年04月14日(中国期刊网平台首次上网日期,不代表论文的发表时间)