摘要
ObjectivesTostudytherelationshipbetweenplasmaBNPandcardiacstructural,functionalchangesafterAMI,andtoevaluatetheapplicationofplasmaBNPdeterminationinpredictingtheearlyphaseofventricleremodelingafterAMI.MethodsAMIgroupincluded37patients,allpatientunderwentstrictmedicaltreatment;32healthyindividualswereenrolledascontrols.PlasmaBNPwasdeterminatedbyimmunofluorescence.EchocardiogramexaminationwasusedtodeterminateLVEF,V_E,V_A,V_E/V_A,LVEDd,LVEDV;Allpatientsunderwenttheexaminationsat72h,30daysand90daysafterAMIoccurred,respectively,andwerecomparedwithhealthycontrols.ResultsIncomparingtocontrols,PlasmaBNPinAMI72h,30daysand90dayselevatedsignificantly.LVEDdandLVEDVwereincreasedsignificantlyinall3phasesofAMI,andEF,V_E/V_Aweresignificantlylowerthanincontrols.CorrelationanalysisrevealedthatplasmaBNPlevelin72hafterAMIwaspositivelycorrelatedtoLVEDd,LVEDV,andwaspositivelycorrelatedtoEF,V_E/V_Ain30daysand90daysafterAMI.ConclusionsPlasmaBNPlevelin72hafterAMIisapowerfulindextopredictleftventricleremodelingandventriclefunctionasplasmBNPlevelispositivelycorrelatedtoventricleremodeling;loweringtheplasmBNPlevelmightbeusedasanendpointfortreatmentofheartfailure.
出版日期
2009年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
