Effect of intracranial pressure and cerebral perfusion pressure on outcome prediction of severe traumatic brain injury-中国期刊网

摘要 Objective:Toinvestigatetheinfluenceofintracranialpressure(ICP)andcerebralperfusionpressure(CPP)onneurologicaldeteriorationandoutcomeofseveretraumaticbraininjury(STBI).Methods:Atotalof245patientswithseveretraumaticbraininjurywerestudiedretrospectivelywithunivariateandmultivariatestudiestoevaluatethecontributionofICP/CPPtoneurologicaldeteriorationandoutcome.Results:Themortalityratesrosefrom16.2%in142patientswhosecourseofdiseasewassmoothto66.7%in103patientswhosufferedfromneurologicaldeterioration.Correspondingly,thefavorableoutcomefallfrom54.2%inthepatientswithoutneurologicaldeteriorationto18.3%inthosewithneurologicaldeterioration.Inthepatientswithclinicalevidenceofneurologicaldeterioration,therelativeinfluenceoftheICPandtheCPPonoutcomewasassessed.Themosepowerfulpredictorsofneurologicaldeteriorationwasthepresenceofintracranialhypertension(ICP>30mmHg,1mmHg=0.133kPa).TheCPPalsohadaprognosticpoweronneurologicaldeteriorationwhenitslevellessthan60mmHg.Conclusions:Itsuggeststhatit'sveryimportanttolowertheintracranialhypertensionandkeeptheCPPnotlessthan60mmHgduringthetreatmentofSTBI.

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Effect of intracranial pressure and cerebral perfusion pressure on outcome prediction of severe traumatic brain injury

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Effect of intracranial pressure and cerebral perfusion pressure on outcome prediction of severe traumatic brain injury

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